云克隆產(chǎn)品助力II型心腎綜合征研究
II型心腎綜合征（Type II cardiorenal syndrome，CRSII）屬于心腎綜合征最為嚴(yán)重的一種，是由慢性心臟功能不全導(dǎo)致腎損傷或腎功能不全，腎功能不全也一定程度上決定了慢性心力衰竭（Chronic heart failure, CHF）患者的預(yù)后。目前對(duì)CRSII的認(rèn)識(shí)還十分有限，由于其發(fā)生率高、預(yù)后差，對(duì)其發(fā)生機(jī)制所知甚少，加之缺乏針對(duì)性強(qiáng)的有效措施，目前仍是臨床醫(yī)師面臨的一個(gè)難題。南方醫(yī)科大學(xué)器官衰竭研究國(guó)家重點(diǎn)實(shí)驗(yàn)室國(guó)家腎臟病臨床醫(yī)學(xué)研究中心侯凡凡院士及其團(tuán)隊(duì)，在II型心腎綜合征的發(fā)病機(jī)理研究上取得重大突破，并將其研究成果“Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome”發(fā)表在腎臟病研究領(lǐng)域的著名期刊《kidney international》上。該團(tuán)隊(duì)基于手術(shù)縮窄主動(dòng)脈弓建立的小鼠心力衰竭模型研究，首次提出了II型心腎綜合征發(fā)病的分子機(jī)理圖，為II型心腎綜合征的預(yù)防和治療提供可重要參考。
Schematic diagram depicts cardiorenal inter-organ cross talk after TAC. Heart injury following TAC activates Wnt/ b -catenin and renin-angiotensin system (RAS) and leads to systemic inflammation with upregulation of TNF- a , IL-1 b , and monocyte chemoattractant protein (MCP)-1 in the circulation. Proinflammatory cytokines in the circulation subsequently suppresses renal klotho expression, which leads to the activation of Wnt/β -catenin and RAS in the kidney and causes podocyte and tubular injury and fibroblast activation. As the main source of systemic klotho, depressed renal production of klotho in the damaged kidney directly causes klotho deficiency in the circulation, which further aggravates Wnt-mediated cardiomyocyte hypertrophy and cardiac fibroblast activation after TAC, forming a vicious cycle. (Yue Zhao, etc. 2019)
侯凡凡院士及其團(tuán)隊(duì)在研究中，來(lái)自云克隆的產(chǎn)品幾乎承接所有關(guān)鍵指標(biāo)的檢測(cè)。最主要的細(xì)胞因子TNF- a、MCP-1、 IL-1 b檢測(cè)全部來(lái)自于云克隆，分別為SEA133Mi（ELISA Kit for Tumor Necrosis Factor Alpha (TNFa)）、SEA087Mi（ELISA Kit for Monocyte Chemotactic Protein 1 (MCP1)）、SEA563Mu（ELISA Kit for Interleukin 1 Beta (IL1b)）；腎臟損傷的關(guān)鍵檢測(cè)指標(biāo) klotho以及與心臟損傷的關(guān)鍵檢測(cè)指標(biāo)BNP，同樣也全部來(lái)源于云克隆，分別為SEH757Mu（ELISA Kit for Klotho (KL)）和SEA541Mu（ELISA Kit for Brain Natriuretic Peptide (BNP)）。云克隆產(chǎn)品以過(guò)硬的質(zhì)量和品質(zhì)得到了院士團(tuán)隊(duì)的青睞，借以南方醫(yī)科大學(xué)器官衰竭研究國(guó)家重點(diǎn)實(shí)驗(yàn)室平臺(tái)為II型心腎綜合征的研究貢獻(xiàn)了一份綿薄之力。
該篇文章中所檢測(cè)指標(biāo)，云克隆其他與之相關(guān)的產(chǎn)品和文獻(xiàn)引用量：
