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Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體

Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP)

P1NP; N-Propeptide Of Type I Procollagen; Procollagen I Amino Terminal Propeptide

編號PAA957Hu08
物種Homo sapiens (Human，人)相同的名稱，不同的物種。
來源多抗制備
宿主兔
效價-
Ig類型IgG
純化方式抗原特異性親和純化
標(biāo)記物無標(biāo)記物
免疫原CPA957Hu31-Ⅰ型前膠原氨基端原肽(PINP)鑰孔血藍(lán)蛋白偶聯(lián)物
緩沖液成份磷酸鹽緩沖液（pH7.4,含有0.02% NaN3和50%甘油）
性狀液體
濃度0.47mg/ml
且適物種-
應(yīng)用IHC
如果抗體需用于流式細(xì)胞術(shù)，請參見流式抗體。
下載英文說明書中文說明書
規(guī)格20μl100μl200μl1ml10ml
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)

Vector Red staining on IHC-P; Samples: Human Skin Tissue; Primary Ab: 10μg/ml Rabbit Anti-Human PINP Antibody Second Ab: 2μg/mL?HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證

特異性

該抗體是針對PINP的兔多克隆抗體。在免疫組織化學(xué)染色和免疫印跡實(shí)驗(yàn)中能識別PINP。

用法

Western blotting: 0.01-2μg/mL;
Immunohistochemistry: 5-20μg/mL;
Immunocytochemistry: 5-20μg/mL;
Optimal working dilutions must be determined by end user.

儲存

經(jīng)常使用則4°C保存。-20°C保存不超過兩年。避免反復(fù)凍融。

穩(wěn)定性

熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。

贈品

增值服務(wù)

抗體標(biāo)記定制服務(wù)
Protein-A/G純化柱
 磷酸化抗體定制服務(wù)
免疫印跡(WB)實(shí)驗(yàn)服務(wù)
免疫沉淀(IP)實(shí)驗(yàn)服務(wù)
TBST 緩沖液
 TBS緩沖液
 TRIS緩沖液

參考文獻(xiàn)

雜志	參考文獻(xiàn)
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Clinical Biochemistry	Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum[ScienceDirect: S0009912012001543]
Therapeutic Apheresis and Dialysis	Low molecular weight iron dextran increases fibroblast growth factor-23 concentration, together with parathyroid hormone decrease in hemodialyzed patients[PubMed: 22458393]
International Journal of Clinical & Experimental Pathology	IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT)[PubMed: PMC3726963]
Osteoporosis International	PINP as a biological response marker during teriparatide treatment for osteoporosis[Pubmed: 24599274]
Clinical Cancer Research	Zoledronic acid has differential anti-tumour activity in the pre-and post-menopausal bone microenvironment in vivo[Aacrjournals: Source]
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Pharmacology	Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy[PubMed: 25871861]
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Sci Rep.?	Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice.[pubmed:28303909]
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SCIENCE & TECHNOLOGY	A Study Protocol: Spinal Morphology, Physical Performance, Quality of Life and Biochemical Markers in Adults at Risk of Osteoporotic Fractures [59f7c85aaca272607e2d8d7a]
Knee Surg Sports Traumatol Arthrosc	Achilles tendon rupture healing is enhanced by intermittent pneumatic compression upregulating collagen type I synthesis[pubmed:28668970]
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Clinical Cases in Mineral and Bone Metabolism	Periostin and sclerostin levels in juvenile Paget's disease[pubmed:29263750]
Journal of Clinical Research in Pediatric Endocrinology	Congenital Hypothyroidism and Bone Remodeling Cycle[pubmed:27840329]
Biomarkers Medicial	Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus[pubmed:28685602]
Heart and Vessels	Left ventricular reverse remodeling is not related to biopsy?detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR[10.1007/s00380-016-0930-y]
BioMed Research International	Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Research[pubmed:29119115]
Cytokine	12-month patterns of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor are similar in new-onset and chronic dilated cardiomyopathy in patients both with and without cardiac fibrosis.[pubmed:28460256]
Advanced Healthcare Materials	Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events.[pubmed:29120858]
Bone.	The key role of proinflammatory cytokines, matrix proteins, RANKL/OPG and Wnt/β-catenin in bone healing of hip arthroplasty patients[pubmed:29129760]
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Nutrients	Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study[Pubmed:29337906]
Osteoporosis International	Two-year cortical and trabecular bone loss in CKD-5D: biochemical and clinical predictors[Pubmed:28993865]
Journal of Nutrition	Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency[Pubmed:29897564]
European?Journal of Pharmacology	The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism[Pubmed:29428468]
Journal of Clinical Densitometry	Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX study[Pubmed:30076009]
Hernia	Circulating matrix metalloproteinases and procollagen propeptides in inguinal hernia[Pubmed:29484522]
Pharmacology	Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats[Pubmed:29898457]
Nature	Coupling of bone resorption and formation by RANKL reverse signalling[Pubmed: 30185903]
European?Journal of?Medical?Research	Biomechanical and histological analyses of the fracture healing process after direct or prolonged reduction[Pubmed: 30180907]
Sensors	Membrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related Biomarkers[Pubmed: 30181433]
Trials	Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP)?…[Pubmed: 30567604]
International Journal of Cancer	Effect of induction therapy with lenalidomide, doxorubicin, and dexamethasone on bone remodeling and angiogenesis in newly diagnosed multiple myeloma[Pubmed: 30650184]
Bone	Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis[Pubmed: 30610968]
Revista de Chimie -Bucharest-	Quantification of N-Terminal Procollagen I Propeptide in Patients With Occlusal Trauma Induced by Prosthetic Factors[]
PLOS?ONE	Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in mice[Pubmed: 30870491]
Scientific Reports	Low fibrosis biomarker levels predict cardiac resynchronization therapy response[Pubmed: 30988339]
Current Developments in Nutrition	Changes in Calciotropic Hormones and Bone Markers During Pregnancy in Response to a Nutrition+ Exercise Intervention in the Be Healthy in Pregnancy RCT (P11?…[Pubmed: 31224444]
Stem Cell Research & Therapy	Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB?…[Pubmed: 31324207]
Bone	The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice[Pubmed: 31622775]
International Journal of Basic and Clinical Endocrinology	Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia[Pubmed: 30143940]
Bone	Mice lacking plastin-3 display a specific defect of cortical bone acquisition[Pubmed: 31678489]
International journal of molecular sciences	Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients[Pubmed: 31717649]
Journal of Bone and Mineral Research	BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling[Pubmed: 31914211]
ESC Heart Failure	Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers[Pubmed: 32064780]
International Journal of Medical Sciences	Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients[Pubmed: 31839746]
JOURNAL OF BONE AND MINERAL RESEARCH	Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation[Pubmed: 33180356]
JOURNAL OF THROMBOSIS AND THROMBOLYSIS	Extracellular matrix collagen biomarkers levels in patients with chronic thromboembolic pulmonary hypertension[Pubmed: 33175289]
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES	Development of a novel polysaccharide-based iron oxide nanoparticle to prevent iron accumulation-related osteoporosis by scavenging reactive oxygen?…[Pubmed: 33049237]
journal of bone and mineral research	Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone‐specific phenotype[Pubmed: 32369212]
Endokrynologia Polska	FGF23 and primary hyperparathyroidism: is there a link?[Pubmed: 32598019]
Journal of Orthopaedic Translation	Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomized rats[]
Research square	4-Hexylresorcinol Inhibits Osteoclastogenesis by Suppressing NF‐κB Signaling Pathway and Reverses Bone Loss in Ovariectomized Mice[]
	淫羊藿水提物及提取藥渣的抗骨質(zhì)疏松藥效比較研究[]
Pamukkale T?p Dergisi	Postmenapozal Tip-2 diyabetes mellitus' lu hastalarda osteoporoza ba?l? k?r?k riskinin ve kemik Turnoveri'nin de?erlendirilmesi[]
International Journal of Pharmaceutical and Clinical Research	Bone Turnover Markers in Osteogenesis Imperfecta and Effect of Bisphosphonate Treatment: First Egyptian Study[]
Science Advances	A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair[33310848]
Rheumatology	Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis[33221885]
Nutrients	Low Energy Availability with and without a High-Protein Diet Suppresses Bone Formation and Increases Bone Resorption in Men: A Randomized Controlled Pilot ?-[33671093]
J Bone Miner Res	Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/\|??\catenin pathway[33950533]
Phytomedicine	Randomized, double-blind, placebo-controlled trial to examine the safety, pharmacokinetics and effects of Epimedium prenylflavonoids, on bone specific alkaline?…[34352588]
Nutrients	The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized?…[34684621]
PLoS One	Osteoblast-specific inactivation of p53 results in locally increased bone formation[34793446]
Bone Res	The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV[34759273]
Nutrients	The Effect of Caloric Restriction with and without n-3 PUFA Supplementation on Bone Turnover Markers in Blood of Subjects with Abdominal Obesity: A Randomized?…[34578973]
Chronobiol Int	Night shift work and osteoporosis-bone turnover markers among female blue-collar workers in Poland[Pubmed:35139709]
Cancers (Basel)	Spine Metastases in Immunocompromised Mice after Intracardiac Injection of MDA-MB-231-SCP2 Breast Cancer Cells[Pubmed:35158823]
Cell Death Discov	BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis[Pubmed:35523787]
Experimental and Molecular Medicine	Foxf2 represses bone formation via Wnt2b/β-catenin signaling[Pubmed:35668101]
Bioactive Materials	Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles[Pubmed:35386445]
Journal of Orthopaedic Translation	Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway[Pubmed:35228997]
Bioactive Materials	Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg–Ca–Zn–Ag alloy to inhibit bacterial infection and promote?…[Pubmed:35585377]
Journal of Orthopaedic Translation	Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35?…[]

編號	適用物種：Homo sapiens (Human，人)	應(yīng)用(僅供研究使用，不用于臨床診斷！)
RPA957Hu02	Ⅰ型前膠原氨基端原肽(PINP)重組蛋白	Positive Control; Immunogen; SDS-PAGE; WB.
APA957Hu61	Ⅰ型前膠原氨基端原肽(PINP)活性蛋白	Cell?culture;?Activity?Assays.
RPA957Hu01	Ⅰ型前膠原氨基端原肽(PINP)重組蛋白	Positive Control; Immunogen; SDS-PAGE; WB.
EPA957Hu61	Ⅰ型前膠原氨基端原肽(PINP)真核蛋白	Positive Control; Immunogen; SDS-PAGE; WB.
SPA957Hu02	Ⅰ型前膠原氨基端原肽(PINP)合成多肽	Immunogen; Blocking Peptide.
CPA957Hu12	Ⅰ型前膠原氨基端原肽(PINP)牛血清白蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
CPA957Hu32	Ⅰ型前膠原氨基端原肽(PINP)鑰孔血藍(lán)蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
CPA957Hu31	Ⅰ型前膠原氨基端原肽(PINP)鑰孔血藍(lán)蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
CPA957Hu22	Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
CPA957Hu23	Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
CPA957Hu21	Ⅰ型前膠原氨基端原肽(PINP)卵白蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
SPA957Hu01	Ⅰ型前膠原氨基端原肽(PINP)合成多肽	Immunogen; Blocking Peptide.
CPA957Hu11	Ⅰ型前膠原氨基端原肽(PINP)牛血清白蛋白偶聯(lián)物	Immunogen; SDS-PAGE; WB.
PAA957Hu08	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體	IHC
PAA957Hu09	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體	WB
PAA957Hu01	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體	WB
PAA957Hu02	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體	WB; IHC; ICC; IP.
LAA957Hu81	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體(異硫氰酸熒光素標(biāo)記)	WB; IHC; ICC; IF.
LAA957Hu71	Ⅰ型前膠原氨基端原肽(PINP)多克隆抗體(生物素標(biāo)記)	WB; IHC; ICC.
MAA957Hu22	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB
RAA957Hu23	Ⅰ型前膠原氨基端原肽(PINP)重組抗體	WB; IF; ICC; IHC; IP; FCM.
RAA957Hu22	Ⅰ型前膠原氨基端原肽(PINP)重組抗體	WB; IF; ICC; IHC; IP; FCM.
MAA957Hu24	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB; IHC; ICC; IP.
MAA957Hu21	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB
MAA957Hu28	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB
MAA957Hu23	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	IHC
MAA957Hu26	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	ICC/IF
MAA957Hu25	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB; IHC; ICC; IP.
MAA957Hu27	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB; IHC; ICC; IP.
MAA957Hu29	Ⅰ型前膠原氨基端原肽(PINP)單克隆抗體	WB; IHC; ICC; IP.
SEA957Hu	Ⅰ型前膠原氨基端原肽(PINP)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法)	Enzyme-linked immunosorbent assay for Antigen Detection.
IEA957Hu	Ⅰ型前膠原氨基端原肽(PINP)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法,快捷型)	Enzyme-linked immunosorbent assay for Antigen Detection.
CEA957Hu	Ⅰ型前膠原氨基端原肽(PINP)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法)	Enzyme-linked immunosorbent assay for Antigen Detection.
LMA957Hu	Ⅰ型前膠原氨基端原肽(PINP)等多因子檢測試劑盒(流式熒光發(fā)光法)	FLIA Kit for Antigen Detection.
PSA957Hu01	Ⅰ型前膠原氨基端原肽(PINP)抗體對	ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
KSA957Hu11	Ⅰ型前膠原氨基端原肽(PINP)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法)	Main materials for "Do It (ELISA Kit) Yourself".
KSA957Hu01	Ⅰ型前膠原氨基端原肽(PINP)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法)	自己動手制作ELISA試劑盒的主要材料

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