胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)
Multiplex Assay Kit for Insulin (INS) ,etc. by FLIA (Flow Luminescence Immunoassay)
（注：單次混測多因子不超過8個指標 ）
- 編號LMA448Gu
- 物種Cavia (Guinea pig ，豚鼠)相同的名稱，不同的物種。
- 實驗方法競爭抑制
- 反應(yīng)時長1.5h
- 檢測范圍9.77-10000pg/mL
- 靈敏度最小可檢測劑量小于等于3.257 pg/mL.
- 樣本類型Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
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產(chǎn)品包裝(模擬)
通過ISO 9001、ISO 13485質(zhì)量體系認證
特異性
本試劑盒用于檢測胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)，經(jīng)檢測與其它相似物質(zhì)無明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來源的限制，不可能完成對所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測，因此本試劑盒有可能與未經(jīng)檢測的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)（加標樣品），重復(fù)測定并計算其均值，回收率為測定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 79-91 | 85 |
| EDTA plasma(n=5) | 84-105 | 92 |
| heparin plasma(n=5) | 93-102 | 97 |
精密度
精密度用樣品測定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對低、中、高值定值樣本進行定量檢測,每份樣本連續(xù)測定20 次，分別計算不同濃度樣本的平均值及SD值。
批間差：選取3個不同批次的試劑盒分別對低、中、高值定值樣本進行定量測定，每個樣本使用同一試劑盒重復(fù)測定8次，分別計算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)，并倍比稀釋成1:2，1:4，1:8，1:16的待測樣本，線性范圍即為稀釋后樣本中胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)含量的測定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 90-104% | 90-98% | 78-101% | 89-102% |
| EDTA plasma(n=5) | 99-105% | 81-94% | 79-103% | 87-96% |
| heparin plasma(n=5) | 93-105% | 93-101% | 98-105% | 90-101% |
穩(wěn)定性
經(jīng)測定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對試劑盒破壞前后檢測值的影響，實驗室的環(huán)境條件需盡量保持一致，尤其是實驗室內(nèi)溫度、濕度及溫育條件。其次由同一實驗員來進行操作可減少人為誤差。
實驗流程
1. 實驗前標準品、試劑及樣本準備；
2. 加樣（標準品、樣本、磁珠、檢測溶液A）標準品或樣本50μL及磁珠10μL，加檢測溶液A50μL，
37°C酶標板振蕩器孵育60分鐘；
3. 磁吸洗板3次；
4. 加檢測溶液B100μL，37°C振動孵育30分鐘；
5. 磁吸洗板3次；
6. 加鞘液100μL，旋渦震蕩2分鐘后讀數(shù)。
實驗原理
將胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)抗體包被于磁珠，制成固相載體，向微孔中分別加入標準品或標本以及磁珠、標記VEGFA，標記的胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)和未標記的胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)與連接于固相載體上的抗體競爭結(jié)合，然后將未結(jié)合物洗凈后，加入PE標記的親和素，再次徹底洗滌后即可上機讀數(shù)。MFI值和樣品中的胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法)呈負相關(guān)。
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| 編號 | 適用物種：Cavia (Guinea pig ，豚鼠) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| RPA448Gu01 | 胰島素(INS)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPA448Gu21 | 胰島素(INS)卵白蛋白偶聯(lián)物 | Immunogen; SDS-PAGE; WB. |
| PAA448Gu01 | 胰島素(INS)多克隆抗體 | WB |
| PAA448Gu08 | 胰島素(INS)多克隆抗體 | WB; IHC; ICC; IP. |
| MAA448Gu21 | 胰島素(INS)單克隆抗體 | WB; IHC; ICC; IP. |
| CEA448Gu | 胰島素(INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA448Gu | 胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
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| Naunyn-Schmiedebergs Archives of Pharmacology | Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway[Pubmed: 31420722] |
| Nutrients | High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights?…[] |
| Cells | MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model[Pubmed: 31540304] |
| Molecular and cellular endocrinology | Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway[Pubmed: 31647955] |
| Obesity Surgery | Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain[Pubmed: 31605365] |
| Surgical Endoscopy and Other Interventional Techniques | Distal gastric mucosa ablation induces significant weight loss and improved glycemic control in type 2 diabetes Sprague–Dawley rat model[Pubmed: 31630290] |
| Biomedicine & Pharmacotherapy | Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats[Pubmed: 31545258] |
| International Journal of Endocrinology | miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling[Pubmed: 31662747] |
| Food & Function | Depolymerized RG-I enriched pectin from citrus segment membrane modulates gut microbiota, increases SCFAs production, promotes the growth of Bifidobacterium?…[Pubmed: 31778135] |
| Life Sciences | P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of toll like receptor-4 in rats[Pubmed: 31629762] |
| Journal of Ovarian Research | Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase[Pubmed: 31722718] |
| journal of ethnopharmacology | Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model[Pubmed: 31756448] |
| Brain Research | Isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice[Pubmed: 31672472] |
| Journal of Ethnopharmacology | San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models[Pubmed: 31843573] |
| Journal of Hazardous Materials | Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice[Pubmed: 31796355] |
| Journal of Steroid Biochemistry and Molecular Biology | SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway[Pubmed: 31785377] |
| Journal of dermatological treatment | Liraglutide improved inflammation via mediating IL-23/Th-17 pathway in obese diabetic mice with psoriasiform skin[Pubmed: 31868553] |
| Nutrients | Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes Rats[Pubmed: 31887996] |
| JOURNAL OF DAIRY SCIENCE | Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by using rumen-protected leucine …[Pubmed: 32113753] |
| Biomed Pharmacother | Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice[Pubmed: 32035395] |
| Frontiers in Endocrinology | Hyperbaric oxygen ameliorates insulin sensitivity by increasing GLUT4 expression in skeletal muscle and stimulating UCP1 in brown adipose tissue in T2DM …[Pubmed: 32082261] |
| Cell Physiol Biochem | Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model.[Pubmed: 31972071] |
| JOURNAL OF FOOD SCIENCE | Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats[Pubmed: 32249934] |
| Journal of Diabetes Research | Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway[Pubmed: 32309446] |
| Brain Research | Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway[Pubmed: 32304687] |
| endocrine journal | Mice with nucleus tractus solitarius injury induced by chronic restraint stress present impaired ability to raise blood glucose and glucagon levels when blood glucose?…[Pubmed: 32249244] |
| Frontiers in Endocrinology | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis[Pubmed: 32328034] |
| Antioxidants | Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes[Pubmed: 33203103] |
| Nature Communications | AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis[Pubmed: 33199780] |
| EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats[Pubmed: 33197556] |
| BIOLOGICAL RESEARCH | Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance?…[Pubmed: 33109277] |
| FASEB JOURNAL | Irradiation of carotid baroreceptor with low‐intensity pulsed ultrasound exerts different metabolic protection in perirenal, epididymal white adipose tissue and?…[Pubmed: 32954574] |
| Biol Res | Palmatine ameliorates high fat diet induced impaired glucose tolerance[Pubmed: 32928312] |
| ENDOCRINE | Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction[Pubmed: 32892310] |
| DIABETOLOGIA | Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via?…[Pubmed: 32880686] |
| AMERICAN JOURNAL OF PATHOLOGY | Insulin promotes corneal nerve repair and wound healing in type 1 diabetic mice by enhancing Wnt/β-catenin signaling[Pubmed: 32858016] |
| MEDIATORS OF INFLAMMATION | Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition[Pubmed: 32801992] |
| EUROPEAN JOURNAL OF PHARMACOLOGY | Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways[Pubmed: 32758573] |
| ARCHIVES OF GYNECOLOGY AND OBSTETRICS | MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance[Pubmed: 32757043] |
| CHEMICO-BIOLOGICAL INTERACTIONS | Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus[Pubmed: 32710900] |
| Mol Med | Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic?…[Pubmed: 32698821] |
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | Highly Branched RG-I Domain Enrichment are Indispensable for Pectin Mitigating Against High-Fat Diet-Induced Obesity[Pubmed: 32633953] |
| Scientific Reports | Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats[Pubmed: 32616735] |
| J Endocrinol Invest | Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats[Pubmed: 32588381] |
| J Chem Neuroanat | The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study[Pubmed: 32479899] |
| Journal of Diabetes Research | Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus[Pubmed: 33123597] |
| Journal of Cellular and Molecular Medicine | Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats[Pubmed: 32395890] |
| BioMed Research International | Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress[Pubmed: 32685488] |
| Frontiers in Pharmacology | MiR-185-5p Protects Against Angiogenesis in Polycystic Ovary Syndrome by Targeting VEGFA[Pubmed: 32760272] |
| Iranian Journal of Basic Medical Sciences | Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS[] |
| Nutrition & Metabolism | Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut?…[] |
| Journal of Functional Foods | Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats[] |
| Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds[] | |
| The effects of different intensity endurance and resistance exercise on diabetic-related blood profiles in impaired glucose tolerance mice[] | |
| Cell Death & Disease | Phosphorylation of eIF2|á signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner[33318479] |
| Ther Adv Chronic Dis | Empagliflozin improves chronic hypercortisolism-induced abnormal myocardial structure and cardiac function in mice[33294147] |
| Physiol Behav | Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1|á expression and activity[33412190] |
| PLoS Genetics | Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds[33370292] |
| Mol Med Rep | N1?methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC?1|á signaling pathway[33576435] |
| Arch Endocrinol Metab | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study[33740335] |
| Sci Rep | Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats[33833309] |
| PeerJ | miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats[33868799] |
| JOURNAL OF FOOD BIOCHEMISTRY | Identification of curcumin as a potential |á?\glucosidase and dipeptidyl?\peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation[33817806] |
| JOURNAL OF NUTRITIONAL BIOCHEMISTRY | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver??-[33915261] |
| Cell Metab | TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease[34107313] |
| Dapagliflozin: a Sodium-glucose Cotransporter 2 Inhibitor, Attenuates Angiotensin II-induced Cardiac Fibrotic Remodeling by Regulating TGF|?1/Smad ?-[34116674] | |
| EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY | Different Ratios of Corn and Coconut Oil Blends in High?\Fat Diets Influence Fat Deposition without Altering Metabolic Biomarkers in Male Rats[] |
| Journal of Alzheimer's disease | DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Up-regulating cAMP/PKA/CREB??-[] |
| International Journal of Diabetes in Developing Countries | Investigation of extracellular matrix genes associated with Alzheimer's disease in the hippocampus of experimental diabetic model rats[] |
| researchsquare | Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats[] |
| Cells Tissues Organs | Intermittent Fasting Attenuates High Fat Diet-Induced Cerebellar Changes in Rats: Involvement of TNFα, autophagy and oxidative stress[34551416] |
| Experimental Biology and Medicine | Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats[34550826] |
| Phytomedicine | Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling[34923235] |
| Pharmacol Res | Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability[34896249] |
| Eat Weight Disord | Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice[34370270] |
| Food Chem Toxicol | Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats[34329744] |
| Eur J Pharmacol | Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor[Pubmed:34973950] |
| Surgical Endoscopy | The effect of bariatric surgery on the expression of Growth Differentiation Factor-15/Macrophage-Inhibitory Cytokine-1 (GDF-15/MIC-1) in rat[Pubmed:35029766] |
| Arch Biochem Biophys | ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice[Pubmed:34990584] |
| Environ Sci Pollut Res Int | Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet[Pubmed:35217953] |
| Naunyn Schmiedebergs Arch Pharmacol | Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice[Pubmed:35201390] |
| PLoS One | A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students[Pubmed:35381008] |
| Cell Death & Disease | Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance[Pubmed:35347118] |
| Endocr J | A novel anti-obesity mechanism for liraglutide by improving adipose tissue leptin resistance in high-fat diet-fed obese mice[Pubmed:35705299] |
| Antioxidants | Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice[Pubmed:35740008] |
| Mol Cell Endocrinol | Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2[Pubmed:35654225] |
| Biofabrication | Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells[Pubmed:35616388] |
| Ecotoxicology and Environmental Safety | Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero[Pubmed:35679725] |
| SAUDI J BIOL SCI | Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain?…[Pubmed:35531250] |
| Saudi Pharmaceutical Journal | Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic?…[Pubmed:35812141] |
| Turk J Diab Obes | An Investigation of the Effect of Curcumin on Fructose-Induced Metabolic Syndrome Rat Models[] |
| Journal of Drug Delivery Science and Technology | Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats[] |
| Genes & Diseases | Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue[] |