胰島素(INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法)
ELISA Kit for Insulin (INS)
- 編號CEA448Ra
- 物種Rattus norvegicus (Rat，大鼠)相同的名稱，不同的物種。
- 實驗方法競爭抑制
- 反應(yīng)時長2h
- 檢測范圍123.5-10,000pg/mL
- 靈敏度最小可檢測劑量小于等于51.6pg/mL.
- 樣本類型serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- 下載英文說明書 中文說明書
- 規(guī)格48T96T96T*596T*1096T*100
- 價格¥ 2873¥ 4104¥ 18468¥ 34884¥ 287280
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)
實驗結(jié)果圖
標(biāo)準(zhǔn)曲線圖
通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
特異性
本試劑盒用于檢測胰島素(INS)，經(jīng)檢測與其它相似物質(zhì)無明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來源的限制，不可能完成對所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測，因此本試劑盒有可能與未經(jīng)檢測的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的胰島素(INS)（加標(biāo)樣品），重復(fù)測定并計算其均值，回收率為測定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 81-94 | 90 |
| EDTA plasma(n=5) | 81-90 | 85 |
| heparin plasma(n=5) | 95-102 | 98 |
精密度
精密度用樣品測定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對低、中、高值定值樣本進行定量檢測,每份樣本連續(xù)測定20 次，分別計算不同濃度樣本的平均值及SD值。
批間差：選取3個不同批次的試劑盒分別對低、中、高值定值樣本進行定量測定，每個樣本使用同一試劑盒重復(fù)測定8次，分別計算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的胰島素(INS)，并倍比稀釋成1:2，1:4，1:8，1:16的待測樣本，線性范圍即為稀釋后樣本中胰島素(INS)含量的測定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 85-93% | 86-93% | 97-105% | 82-101% |
| EDTA plasma(n=5) | 94-101% | 78-104% | 89-103% | 81-97% |
| heparin plasma(n=5) | 94-104% | 91-102% | 85-99% | 81-93% |
穩(wěn)定性
經(jīng)測定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對試劑盒破壞前后檢測值的影響，實驗室的環(huán)境條件需盡量保持一致，尤其是實驗室內(nèi)溫度、濕度及溫育條件。其次由同一實驗員來進行操作可減少人為誤差。
實驗流程
1. 實驗前標(biāo)準(zhǔn)品、試劑及樣本的準(zhǔn)備；
2. 加樣（標(biāo)準(zhǔn)品及樣本）50µL，
加入50µL檢測液A(臨用前配制);
37°C溫育1小時。
3. 洗板3次；
4. 加檢測溶液B100µL，37°C孵育30分鐘；
5. 洗板5次；
6. 加TMB底物90µL，37°C孵育10-20分鐘；
7. 加終止液50µL，立即450nm讀數(shù)。
實驗原理
本試劑盒應(yīng)用競爭抑制酶聯(lián)免疫分析法測定標(biāo)本中待測物質(zhì)水平。將胰島素(INS)單克隆抗體包被微孔板，制成固相載體，往包被抗體的微孔中同時加入生物素標(biāo)記的抗原和待測抗原(標(biāo)準(zhǔn)品或樣本)，待測抗原與生物素標(biāo)記抗原對特異性抗體進行競爭結(jié)合。溫育后經(jīng)洗滌去掉未結(jié)合物，然后加入HRP標(biāo)記的親和素，經(jīng)過溫育和徹底洗滌后加入底物TMB顯色。TMB在過氧化物酶的催化下轉(zhuǎn)化成藍色，并在酸的作用下轉(zhuǎn)化成最終的黃色。待測標(biāo)本濃度越高，標(biāo)記抗原和抗體的結(jié)合就越受到抑制，顯色愈淺。顯色的深淺與酶量呈正相關(guān)，而與樣品中待測物質(zhì)含量呈負(fù)相關(guān)。用酶標(biāo)儀在450nm波長下測定吸光度（O.D.值），計算樣品濃度。
增值服務(wù)
相關(guān)產(chǎn)品
| 編號 | 適用物種：Rattus norvegicus (Rat，大鼠) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| NPA448Ra01 | 胰島素(INS)天然蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA448Ra01 | 胰島素(INS)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA448Ra01 | 胰島素(INS)多克隆抗體 | WB; IHC |
| MAA448Ra21 | 胰島素(INS)單克隆抗體 | WB; IHC; ICC; IP. |
| CEA448Ra | 胰島素(INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| MEA448Ra | 胰島素(INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法,小樣本) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEA448Ra | 胰島素(INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法,高敏型) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| AEA448Ra | 抗胰島素抗體(Anti-INS)檢測試劑盒(酶聯(lián)免疫吸附試驗法) | Enzyme-linked immunosorbent assay for Antibody Detection. |
| CCA448Ra | 胰島素(INS)檢測試劑盒(化學(xué)發(fā)光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| LMA448Ra | 胰島素(INS)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| KSA448Ra11 | 胰島素(INS)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗法) | Main materials for "Do It (ELISA Kit) Yourself". |
參考文獻
| 雜志 | 參考文獻 |
| Neuroscience Research | Impaired neural stem/progenitor cell proliferation in Streptozotocin-induced and spontaneous diabetic mice[PubMed: 20832431] |
| International Journal of Nanomedicine | Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway[PubMed: PMC3770514] |
| Mediators of Inflammation | Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation[Pubmed: 24288442] |
| American Journal of Research Communication | Polo Like Kinase 1 (Plk1) Expression in Visceral Adipose Tissue of Morbidly Obese Non Diabetic Women[Usa-journals: Source] |
| Nutr Hosp. | Effect of the “protein diet” and bone tissue.[Pubmed: 24483972] |
| Endocrinology | Rosiglitazone Inhibits Expression and Secretion of PEDF in Adipose Tissue and Liver of Male SD Rats Via a PPAR-γ Independent Mechanism[Endocrine: Source] |
| CORRELA??ES ENTRE METABóLITOS E HORM?NIOS NO PERíODO DE TRANSI??O DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL [Cnptia:Source] | |
| CONCENTRA??ES SéRICAS DE INSULINA NO PóS-PARTO RECENTE DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL[Alice:Source] | |
| Evid Based Complement Alternat Med. | Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats[Pubmed:Pmc4363645] |
| Iran J Basic Med Sci | Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats[Pubmed:Pmc4046234] |
| Biometals.? | Perinatal low-dose iron treatment influences susceptibility to diet-induced adipogenesis in early-aged male Wistar rats[Pubmed:24519243] |
| Asian Pac J Cancer Prev. | Effect of NUCKS-1 Overexpression on cytokine profiling in obese women with breast cancer[Pubmed:24568505] |
| J Ethnopharmacol.? | Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial[Pubmed:24814037] |
| Obes Surg | Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model[PubMed: 26202420] |
| Evid Based Complement Alternat Med | Tinospora crispa[PubMed: 25821506] |
| international journal of biological and chemical sciences | Taraxacum officinale[Index.Php: Ijbcs] |
| FPO | IDENTIFICATION OF MODULATORS OF BINDING PROPERTIES OF ANTIBODIES REACTIVE WITH A MEMBER OF THE INSULIN RECEPTOR FAMILY[Y2015: 0301040.Html] |
| Nutrition | Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein[Pubmed:27158055] |
| European Journal of Pharmacology | Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3尾 pathway in an amyloid 尾 protein induced alzheimer disease mouse model[Pubmed:27131827] |
| Archives of Physiology and Biochemistry | Improvement of oral contraceptive-induced glucose dysreCavia (Guinea pig )lation and dyslipidemia by valproic acid is independent of circulating corticosterone[Pubmed:26855320] |
| Archives of Physiology and Biochemistry | Activation of cardiac renin–angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder[Pubmed:26934364] |
| Cell and Tissue Research | The dynamic three-dimensional culture of islet-like clusters in decellularized liver scaffolds[Pubmed:26796204] |
| Adv Biomed Res. | Trigonella foenum-graecum?water extract improves insulin sensitivity and stimulates?PPAR?and γ gene expression in high fructose-fed insulin-resistant rats[pmc:PMC4817393] |
| Mech Ageing Dev.? | Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway[Pubmed:27041232] |
| J?Bone?Miner Res | Fat and Sucrose Intake Induces Obesity‐Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats[Pubmed:26175082] |
| Scientific Reports | Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus[pubmed:27461373] |
| International Journal of Medical Research Professionals | Low Circulating Vaspin Level is not associated with Insulinemic Status in Impaired Glucose Tolerant Subjects[profile:Muhammad_Saiedullah] |
| Journal of Pharmacy and Nutrition Sciences | Metformin Reduces Oxidative Stress Status and Improves Plasma Insulin Level in Streptozotocin-Induced Diabetic Rats[pms:index.php] |
| 33 | Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome.[pubmed:28336389] |
| Journal of Endocrinology and Metabolism | Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis[405] |
| American Journal of Translational Research | Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β.[pubmed:28337257] |
| Journal of Molecular and Cellular Cardiology | Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice[pubmed:27638193] |
| Scientific Reports | The?anti-hyperglycemic?efficacy?of a?lipid-lowering?drug?Daming?capsule?and the?underlyingsignaling?mechanisms?in a?rat?model?of?diabetes?mellitus.[pubmed:27721485] |
| Scientific Reports | Adiponectin?protects?the?rats?liver?against?chronic?intermittent?hypoxia?induced?injury?throughAMP-activated?protein?kinase?pathway.[pubmed:27678302] |
| Biomedicine & Pharmacotherapy | Vitamin?D3?intake?as?regulator?of?insulin?degrading?enzyme?and?insulin?receptor?phosphorylationin?diabetic?rats.[pubmed:27930980] |
| Eur Neuropsychopharmacol. | Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment.[pubmed:28063625] |
| Molecular and Cellular Endocrinology | Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway[pubmed:28359800] |
| Diabetologia | Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice[pubmed:28280902] |
| ?Biochimica et Biophysica Acta (BBA)-General Subjects | Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats[pubmed:28341485] |
| Journal of Diabetes Research | High plasma glucagon levels correlate with waist-to-hip ratio, supra-iliac skinfold thickness, deep subcutaneous abdominal and intra-peritoneal adipose tissue …[2376016.pdf] |
| IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES | Berberis integerrima ameliorates insulin resistance in high-fructose-fed insulin-resistant rats[pubmed:29147484] |
| Journal of Functional Foods | Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice [10.1016:j.jff.2017.01.044] |
| BMJ Open Diab Res Care | High circulating plasma dipeptidyl peptidase- 4 levels in non-obese Asian Indians with type 2 diabetes correlate with fasting insulin and LDL-C levels, triceps skinfolds, total intra-abdominal adipose tissue volume and presence of diabetes: a case–control study[10.1136:bmjdrc-2017-000393] |
| Archives of Oral Biology | Chronic high-protein diet induces oxidative stress and alters the salivary gland function in rats[pubmed:28926744] |
| clinical?and experimental pharmacology and physiology | C1q/TNF‐related protein 9 improves the anti‐contractile effects of perivascular adipose tissue via the AMPK‐eNOS pathway in diet‐induced obese mice[pubmed:28902432] |
| Cellular Physiology and Biochemistry | Irisin Regulates Heme Oxygenase-1/ Adiponectin Axis in Perivascular Adipose Tissue and Improves Endothelial Dysfunction in Diet-Induced Obese Mice[pubmed:28595178] |
| Peptides | Activiated Galanin receptor 2 attenuates insulin resistance in skeletal muscle of obese mice[pubmed:29183756] |
| Journal of Diabetes Research | High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese Asian Indian Males with Type 2 Diabetes in North India[10.1155/2017/2376016] |
| Mechanisms of Ageing and Development | Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway[pubmed:27041232] |
| Iranian Journal of Pharmaceutical Research | Antihyperglycemic Effect of Rosa Damascena is Mediated by PPAR.γ Gene Expression in Animal Model of Insulin Resistance[pubmed:29201096] |
| Obesity Surgery | Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice[pubmed:28853013] |
| Journal of Current Medical Research and Practice | Relationship between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus[issn/2357-0121] |
| Nanomedicine (Lond) | Nanoformulated natural therapeutics for management of streptozotocin-induced diabetes: potential use of curcumin nanoformulation[pubmed:28635562] |
| Journal of Inorganic Biochemistry | Synthesis and anti-diabetic activity of new N,N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes.[pubmed:28709620] |
| Obesity surgery | The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats.[pubmed:28840471] |
| Biochemical and Biophysical Research Communications | Adipose tissue complement factor B promotes adipocyte maturation.[pubmed:29137982] |
| Oman Medical Journal | The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus.[pubmed:28584599] |
| International Journal of Molecular Medicine | Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle[pubmed:29039450] |
| BMC Complementary and Alternative Medicine | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin[pubmed:28576138] |
| Nutrients | Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats[pubmed:28832548] |
| DARU Journal of Pharmaceutical Sciences | Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway[pubmed:29020999] |
| Journal of Traditional and Complementary Medicine | Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated with Ficus deltoidea leaf extract and vitexin.[pubmed:29322009] |
| World Journal of Pharmaceutical Sciences | The potential role of sitagliptin as an oral treatment regimen for type I diabetes mellitus [ISSN: 2321-3086] |
| Journal of Endocrinology | Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression.[pubmed:28490443] |
| Nature Medicine | The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis[Pubmed:29291351] |
| Surgery for Obesity and Related Diseases | The Effect of Distal-ileal Exclusion After Roux-en-Y Gastric Bypass on Glucose Tolerance and GLP-1 Response in Type-2 Diabetes Sprague-Dawley Rat Model[10.1016:j.soard.2018.07.009] |
| Obesity?Surgery? | Preserving Duodenal-Jejunal (Foregut) Transit Does Not Impair Glucose Tolerance and Diabetes Remission Following Gastric Bypass in Type 2 Diabetes Sprague?…[Pubmed:29098544] |
| Frontiers in Physiology | Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21[Pubmed:29593555] |
| Chemico-Biological Interactions | Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats[Pubmed:29409856] |
| Journal of?Dairy?Science | Effects of dietary leucine and phenylalanine on pancreas development, enzyme activity, and relative gene expression in milk-fed Holstein dairy calves[Pubmed:29477524] |
| Diabetes?research and?clinical?practice | Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice[Pubmed:29526684] |
| Beneficial?Microbes | Anti-obesity properties of the strain subsp. CECT 8145 in Zücker fatty rats[Pubmed:29695181] |
| Canadian Journal of Physiology and Pharmacology | Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats[Pubmed:29510081] |
| Animal Feed Science and Technology | Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows[10.1016:j.anifeedsci.2018.01.012] |
| Journal of Complementary and Integrative Medicine | Diet enriched with fresh coconut decreases blood glucose levels and body weight in normal adults[Pubmed:29461972] |
| Experimental and Therapeutic Medicine | Liraglutide exerts a bone?protective effect in ovariectomized rats with streptozotocin?induced diabetes by inhibiting osteoclastogenesis[Pubmed:29805533] |
| Pakistan Journal of Zoology | Effects of Intrauterine Growth Retardation on Growth, Meat Quality and Muscle Fiber Composition of Pigs.[:] |
| Oncotarget | Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver[Pubmed:29719598] |
| Journal of King Saud University - Science | The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin?…[10.1016:j.jksus.2018.05.017] |
| Chinese Journal of Diabetes Mellitus | 組織蛋白酶G 在1 型糖尿病小鼠CD+ 4T 淋巴細胞活化過程中的作用.[Ebscohost:Source] |
| International?Journal?of?Molecular?Sciences | Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice[Pubmed: 30231545] |
| Journal of Functional Foods | Transcriptomic analysis reveals effects of fucoxanthin on intestinal glucose transport[Doi: 10.1016/j.jff.2018.08.018] |
| Future?Medicine | Targeted folate-conjugated pluronic P85/poly(lactide--glycolide) polymersome for the oral delivery of insulin[Doi: 10.2217/nnm-2017-0372] |
| Cellular?Physiology and Biochemistry | Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice[Pubmed: 30308480] |
| Experimental Gerontology | The decline of whole-body glucose metabolism in ovariectomized rats[Pubmed: 30292771] |
| Neuroscience?Bulletin | Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation Adrenomedullin Receptors in Rats?…[Pubmed: 30276527] |
| Journal?of?Cellular?Biochemistry | Alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with[Pubmed: 30270568] |
| Biological?Rhythm?Research | Effects of feeding frequency during lactation in primiparous sows on reproduction performance and diurnal rhythm of endocrine profiles at the weaning-to-ovulation?…[] |
| Obesity?Surgery | The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery[Pubmed: 30397878] |
| Biochimie | Silencing of LncRNA Steroid Receptor RNA Activator attenuates polycystic ovary syndrome in Mice[Pubmed: 30391287] |
| Archives?of?Medical?Research | Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway[Pubmed: 30409503] |
| Biomedicine & Pharmacotherapy | Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats[Pubmed: 30551463] |
| Journal of Endocrinology | Uterine progesterone signaling is a target for metformin therapy in polycystic ovary syndrome[Pubmed: 29535146] |
| West Indian Medical Journal | Plasma Cellular Hypoxia, Mitochondrial Dysfunction, Disease Risk and Prognostic Factors in Type 2 Diabetic Patients in Saudi Arabia.[] |
| Biomaterials?Science | Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides[Pubmed: 30672923] |
| BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose?…[Pubmed: 30742994] |
| Obesity?Surgery | The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model[Pubmed: 30778846] |
| Journal of Alzheimer's Disease Reports | Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats[] |
| Stress | Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure[Pubmed: 30821572] |
| Life?Sciences | Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats[Pubmed: 30826497] |
| cell?biology international | Regulation of insulin resistance by targeting insulin‐like growth factor 1 receptor (IGF‐1R) with microRNA‐122‐5p in hepatic cells[Pubmed: 30958584] |
| international?journal?of?molecular?sciences | Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice[Pubmed: 30909542] |
| Journal of Clinical and Translational Endocrinology | Dobesity: relationship between vitamin d deficiency, obesity and sclerostin as a novel biomarker of bone metabolism[] |
| Acta Pharmacologica Sinica | Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice[Pubmed: 31213670] |
| Biochemistry | Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells[] |
| Physiological Research | Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.[Pubmed: 31301730] |
| molecular nutrition & food research | Glycerol Monolaurate‐Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet‐fed Mice[Pubmed: 31318165] |
| Arch Physiol Biochem | Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training[Pubmed: 31290696] |
| Efeito do consumo cr?nico de óleo de coco sobre parametros bioquímicos e do status redox em ratas saudáveis.[] | |
| Diabetes-Metabolism Research and Reviews | Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta‐cells apoptosis via mediating the ASK1/JNK/BAX pathway in [Pubmed: 31411368] |
| Phytomedicine | Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway[] |
| Naunyn-Schmiedebergs Archives of Pharmacology | Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway[Pubmed: 31420722] |
| Nutrients | High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights?…[] |
| Cells | MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model[Pubmed: 31540304] |
| Molecular and cellular endocrinology | Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway[Pubmed: 31647955] |
| Obesity Surgery | Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain[Pubmed: 31605365] |
| Surgical Endoscopy and Other Interventional Techniques | Distal gastric mucosa ablation induces significant weight loss and improved glycemic control in type 2 diabetes Sprague–Dawley rat model[Pubmed: 31630290] |
| Biomedicine & Pharmacotherapy | Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats[Pubmed: 31545258] |
| International Journal of Endocrinology | miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling[Pubmed: 31662747] |
| Food & Function | Depolymerized RG-I enriched pectin from citrus segment membrane modulates gut microbiota, increases SCFAs production, promotes the growth of Bifidobacterium?…[Pubmed: 31778135] |
| Life Sciences | P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of toll like receptor-4 in rats[Pubmed: 31629762] |
| Journal of Ovarian Research | Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase[Pubmed: 31722718] |
| journal of ethnopharmacology | Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model[Pubmed: 31756448] |
| Brain Research | Isoflurane aggravates peripheral and central insulin resistance in high-fat diet/streptozocin-induced type 2 diabetic mice[Pubmed: 31672472] |
| Journal of Ethnopharmacology | San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models[Pubmed: 31843573] |
| Journal of Hazardous Materials | Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice[Pubmed: 31796355] |
| Journal of Steroid Biochemistry and Molecular Biology | SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway[Pubmed: 31785377] |
| Journal of dermatological treatment | Liraglutide improved inflammation via mediating IL-23/Th-17 pathway in obese diabetic mice with psoriasiform skin[Pubmed: 31868553] |
| Nutrients | Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes Rats[Pubmed: 31887996] |
| JOURNAL OF DAIRY SCIENCE | Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by using rumen-protected leucine …[Pubmed: 32113753] |
| Biomed Pharmacother | Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice[Pubmed: 32035395] |
| Frontiers in Endocrinology | Hyperbaric oxygen ameliorates insulin sensitivity by increasing GLUT4 expression in skeletal muscle and stimulating UCP1 in brown adipose tissue in T2DM …[Pubmed: 32082261] |
| Cell Physiol Biochem | Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model.[Pubmed: 31972071] |
| JOURNAL OF FOOD SCIENCE | Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats[Pubmed: 32249934] |
| Journal of Diabetes Research | Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway[Pubmed: 32309446] |
| Brain Research | Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway[Pubmed: 32304687] |
| endocrine journal | Mice with nucleus tractus solitarius injury induced by chronic restraint stress present impaired ability to raise blood glucose and glucagon levels when blood glucose?…[Pubmed: 32249244] |
| Frontiers in Endocrinology | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis[Pubmed: 32328034] |
| Antioxidants | Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes[Pubmed: 33203103] |
| Nature Communications | AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis[Pubmed: 33199780] |
| EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats[Pubmed: 33197556] |
| BIOLOGICAL RESEARCH | Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance?…[Pubmed: 33109277] |
| FASEB JOURNAL | Irradiation of carotid baroreceptor with low‐intensity pulsed ultrasound exerts different metabolic protection in perirenal, epididymal white adipose tissue and?…[Pubmed: 32954574] |
| Biol Res | Palmatine ameliorates high fat diet induced impaired glucose tolerance[Pubmed: 32928312] |
| ENDOCRINE | Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction[Pubmed: 32892310] |
| DIABETOLOGIA | Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via?…[Pubmed: 32880686] |
| AMERICAN JOURNAL OF PATHOLOGY | Insulin promotes corneal nerve repair and wound healing in type 1 diabetic mice by enhancing Wnt/β-catenin signaling[Pubmed: 32858016] |
| MEDIATORS OF INFLAMMATION | Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition[Pubmed: 32801992] |
| EUROPEAN JOURNAL OF PHARMACOLOGY | Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways[Pubmed: 32758573] |
| ARCHIVES OF GYNECOLOGY AND OBSTETRICS | MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance[Pubmed: 32757043] |
| CHEMICO-BIOLOGICAL INTERACTIONS | Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus[Pubmed: 32710900] |
| Mol Med | Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic?…[Pubmed: 32698821] |
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | Highly Branched RG-I Domain Enrichment are Indispensable for Pectin Mitigating Against High-Fat Diet-Induced Obesity[Pubmed: 32633953] |
| Scientific Reports | Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats[Pubmed: 32616735] |
| J Endocrinol Invest | Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats[Pubmed: 32588381] |
| J Chem Neuroanat | The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study[Pubmed: 32479899] |
| Journal of Diabetes Research | Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus[Pubmed: 33123597] |
| Journal of Cellular and Molecular Medicine | Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats[Pubmed: 32395890] |
| BioMed Research International | Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress[Pubmed: 32685488] |
| Frontiers in Pharmacology | MiR-185-5p Protects Against Angiogenesis in Polycystic Ovary Syndrome by Targeting VEGFA[Pubmed: 32760272] |
| Iranian Journal of Basic Medical Sciences | Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS[] |
| Nutrition & Metabolism | Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut?…[] |
| Journal of Functional Foods | Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats[] |
| Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds[] | |
| The effects of different intensity endurance and resistance exercise on diabetic-related blood profiles in impaired glucose tolerance mice[] | |
| Cell Death & Disease | Phosphorylation of eIF2|á signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner[33318479] |
| Ther Adv Chronic Dis | Empagliflozin improves chronic hypercortisolism-induced abnormal myocardial structure and cardiac function in mice[33294147] |
| Physiol Behav | Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1|á expression and activity[33412190] |
| PLoS Genetics | Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds[33370292] |
| Mol Med Rep | N1?methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC?1|á signaling pathway[33576435] |
| Arch Endocrinol Metab | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study[33740335] |
| Sci Rep | Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats[33833309] |
| PeerJ | miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats[33868799] |
| JOURNAL OF FOOD BIOCHEMISTRY | Identification of curcumin as a potential |á?\glucosidase and dipeptidyl?\peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation[33817806] |
| JOURNAL OF NUTRITIONAL BIOCHEMISTRY | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver??-[33915261] |
| Cell Metab | TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease[34107313] |
| Dapagliflozin: a Sodium-glucose Cotransporter 2 Inhibitor, Attenuates Angiotensin II-induced Cardiac Fibrotic Remodeling by Regulating TGF|?1/Smad ?-[34116674] | |
| EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY | Different Ratios of Corn and Coconut Oil Blends in High?\Fat Diets Influence Fat Deposition without Altering Metabolic Biomarkers in Male Rats[] |
| Journal of Alzheimer's disease | DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Up-regulating cAMP/PKA/CREB??-[] |
| International Journal of Diabetes in Developing Countries | Investigation of extracellular matrix genes associated with Alzheimer's disease in the hippocampus of experimental diabetic model rats[] |
| researchsquare | Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats[] |
| Cells Tissues Organs | Intermittent Fasting Attenuates High Fat Diet-Induced Cerebellar Changes in Rats: Involvement of TNFα, autophagy and oxidative stress[34551416] |
| Experimental Biology and Medicine | Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats[34550826] |
| Phytomedicine | Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling[34923235] |
| Pharmacol Res | Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability[34896249] |
| Eat Weight Disord | Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice[34370270] |
| Food Chem Toxicol | Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats[34329744] |
| Eur J Pharmacol | Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor[Pubmed:34973950] |
| Surgical Endoscopy | The effect of bariatric surgery on the expression of Growth Differentiation Factor-15/Macrophage-Inhibitory Cytokine-1 (GDF-15/MIC-1) in rat[Pubmed:35029766] |
| Arch Biochem Biophys | ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice[Pubmed:34990584] |
| Environ Sci Pollut Res Int | Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet[Pubmed:35217953] |
| Naunyn Schmiedebergs Arch Pharmacol | Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice[Pubmed:35201390] |
| PLoS One | A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students[Pubmed:35381008] |
| Cell Death & Disease | Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance[Pubmed:35347118] |
| Endocr J | A novel anti-obesity mechanism for liraglutide by improving adipose tissue leptin resistance in high-fat diet-fed obese mice[Pubmed:35705299] |
| Antioxidants | Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice[Pubmed:35740008] |
| Mol Cell Endocrinol | Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2[Pubmed:35654225] |
| Biofabrication | Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells[Pubmed:35616388] |
| Ecotoxicology and Environmental Safety | Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero[Pubmed:35679725] |
| SAUDI J BIOL SCI | Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain?…[Pubmed:35531250] |
| Saudi Pharmaceutical Journal | Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic?…[Pubmed:35812141] |
| Turk J Diab Obes | An Investigation of the Effect of Curcumin on Fructose-Induced Metabolic Syndrome Rat Models[] |
| Journal of Drug Delivery Science and Technology | Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats[] |
| Genes & Diseases | Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue[] |
